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KMID : 0613820070170050613
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Journal of Life Science
2007 Volume.17 No. 5 p.613 ~ p.618
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Expression analysis of RBMY1, CDY1, and VCY2 genes in Korean male infertility
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Huh Jae-Won
Kim Woo-Young
Kim Dae-Soo
Ha Hong-Seok
Park Nam-Cheol
Choi Uk-Hwan
Kim Heui-Soo
Nam Ki-Man
Choi Jin
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Abstract
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Azoospermia factor (AZFa, b, and c) regions have been focused on their involvement in the spermatogenic process by frequent observation of microdeletion in male infertility. Among the azoospermia factors, RBMY1, CDY1, and VCY2 genes are strongly associated with the male germinal cell differentiation and development in testis. Using RT-PCR approach, expression patterns of RBMY1, CDY1, and VCY2 genes are examined in testicular biopsy specimens from 42 Korean azoospermic patients. No expression of RBMY1, CDY1, and VCY2 genes appeared as 34%, 66%, and 27% of the male infertility, respectively. Patients who had no expression of RBMYl and VCY2 genes also showed negative expression of the CDY1 gene in their testis tissues. All Sertoli cell-only syndrome patients showed no expression of the CDY1 gene. Taken together, the CDY1 gene expression seems to be necessary factor to complete spermatogenesis in Korean population.
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KEYWORD
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CDY1, RBMY1, VCY2, Korean population, male infertility
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